The Zowe zss server on USS may log an error like this on startup
ZIS status - Failure (name='ZWESIS_STD ', cmsRC=46, description='N/A', clientVersion=2)
Some of these errors are explained here
https://zowe.github.io/docs-site/latest/troubleshoot/troubleshoot-app-framework.html#unable-to-log-in-to-the-zowe-desktop
For a complete list of the meaning of cmsRC
values, you can refer to the C header file
zowe/zowe-common-c/h/crossmemory.h
For example, cmsRC=46 means
RC_CMS_SERVICE_NOT_INITIALIZED
which could indicate that you’re using a newer zss with an old zis. To fix this, update the ZWESIS01 member in HLQ.LOADLIB specified on the STEPLIB in the ZSS STC with the latest version, then stop and restart the z/OS ZSS server STC. You don’t have to restart any other Zowe jobs for this to take effect.